TED - Título De Especialista Em Dermatologia Practice Questions - Exame Para Obtenção Do Título De Especialista Em Dermatologia (TED - SBD AMB) Exam

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During the dermatological physical examination of a patient with a generalized eruption, the examiner observes the formation of an epidermal detachment upon applying lateral tangential shearing pressure to normal-appearing perilesional skin. Which clinical sign and associated pathophysiological mechanism are demonstrated?

Nikolsky sign (sinal de Nikolsky), indicating loss of keratinocyte-keratinocyte cell adhesion (acantholysis) or complete basal-suprabasal junctional failure. Asboe-Hansen sign, indicating lateral accumulation of edema within the subcorneal space under mechanical occlusion. Darier sign, indicating sudden degranulation of dermal mastocytes with histamine release upon mechanical stroking. Auspitz sign, indicating exposure of dilated and tortuous dermal papillary capillaries following mechanical removal of adherent parakeratotic scales.

Correct Answer:

Nikolsky sign (sinal de Nikolsky), indicating loss of keratinocyte-keratinocyte cell adhesion (acantholysis) or complete basal-suprabasal junctional failure.

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