Singapore GCE A-Level H3 Biology Practice Questions - Singapore GCE A-Level H3 Biology Examination (SEAB Syllabus 9816) Exam

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Upon ligand binding to the extracellular domain of a Receptor Tyrosine Kinase (RTK), which immediate biochemical event is required to initiate downstream cytoplasmic signalling?

Receptor dimerization leading to trans-autophosphorylation of tyrosine residues in the kinase domain Direct cleavage of the receptor intracellular domain by extracellular matrix metalloproteinases Binding of GTP to the receptor's seven transmembrane domain loop region Phosphorylation of serine and threonine residues by protein kinase A (PKA)

Correct Answer:

Receptor dimerization leading to trans-autophosphorylation of tyrosine residues in the kinase domain

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