Revalida Farmacia UChile Practice Questions - Examen De Revalidación De Título De Químico Farmacéutico (Universidad De Chile) Exam

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What is the molecular mechanism of action of Direct Oral Anticoagulants (DOACs) such as Rivaroxaban, Apixaban, and Edoxaban?

Direct, selective, reversible competitive inhibition of free and clot-bound Factor Xa Direct competitive inhibition of Thrombin (Factor IIa) Inhibition of Vitamin K Epoxide Reductase Complex 1 (VKORC1) Irreversible inhibition of platelet cyclooxygenase-1 (COX-1)

Correct Answer:

Direct, selective, reversible competitive inhibition of free and clot-bound Factor Xa

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