Revalida Farmacia UChile Practice Questions - Examen De Revalidación De Título De Químico Farmacéutico (Universidad De Chile) Exam

Fluconazole strongly inhibits hepatic CYP2C9 (the primary metabolic enzyme for the more potent S-warfarin isomer), markedly increasing warfarin plasma concentrations and significantly elevating INR, leading to severe bleeding risk Fluconazole induces CYP3A4, accelerating warfarin metabolism and decreasing INR Fluconazole binds warfarin in the gut lumen, completely blocking its oral absorption Fluconazole has zero effect on warfarin metabolism