Revalida Farmacia UChile Practice Questions - Examen De Revalidación De Título De Químico Farmacéutico (Universidad De Chile) Exam

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What is the primary molecular mechanism of action of Angiotensin-Converting Enzyme (ACE) inhibitors (e.g., Enalapril) in reducing blood pressure and preventing adverse left ventricular remodeling in heart failure?

Inhibits ACE (peptidyl dipeptidase), blocking the conversion of Angiotensin I to Angiotensin II while simultaneously preventing the degradation of vasodilatory bradykinin Competitively blocks AT1 angiotensin receptors without affecting bradykinin levels Directly stimulates renal beta-1 adrenergic receptors Blocks voltage-gated L-type calcium channels in vascular smooth muscle

Correct Answer:

Inhibits ACE (peptidyl dipeptidase), blocking the conversion of Angiotensin I to Angiotensin II while simultaneously preventing the degradation of vasodilatory bradykinin

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