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Respiratory CAS Practice Exam

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Charcot-Leyden crystals are derived from which cells?
Correct Answer:
Eosinophilic granules
Explanation:
Charcot-Leyden crystals come from eosinophils. They are made from galectin-10, a major protein stored in eosinophil granules. When eosinophils are activated and release their granule contents during allergic or parasitic inflammation, galectin-10 can crystallize and form the characteristic crystals seen in sputum or tissue. This association with eosinophilic inflammation explains why these crystals appear in conditions like asthma and parasitic infections. Neutrophils, platelets, or lymphocytes do not produce these crystals, so their granule contents don’t form Charcot-Leyden crystals.

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