RCPSC Urology Practice Questions - Royal College Certification Examination In Urology Exam

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A 28-year-old man presents with a painless right testicular mass. Ultrasound shows a 3.5 cm heterogeneous intratesticular mass. AFP is normal, beta-hCG is 24 IU/L, and LDH is mildly elevated. He undergoes a right radical inguinal orchiectomy. Pathology confirms a pure seminoma. What is the most likely reason his beta-hCG is elevated?

Seminomas can contain syncytiotrophoblastic giant cells that secrete beta-hCG The presence of occult embryonal carcinoma components The patient has underlying hypogonadism causing cross-reactivity with LH Pure seminomas do not secrete beta-hCG; the pathology diagnosis must be incorrect

Correct Answer:

Seminomas can contain syncytiotrophoblastic giant cells that secrete beta-hCG

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