RCPA BPS Exam Practice Questions - RCPA Basic Pathological Sciences Examination Exam

How is the ATF6 branch of the unfolded protein response activated during endoplasmic reticulum stress?

Mitochondrial cytochrome c release activating ATF6 IRE1 signalling alone, without any ATF6 pathway PERK directly cleaving ATF6 in the cytosol ATF6 translocation to the Golgi followed by proteolytic activation

Correct Answer:

ATF6 translocation to the Golgi followed by proteolytic activation

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