Primary FRCA Practice Questions - Primary FRCA Examination Exam

A drug has a hepatic extraction ratio of 0.9. Which statement best describes its clearance?

Clearance is independent of hepatic blood flow and limited only by enzyme activity Clearance is determined mainly by the unbound fraction of drug in plasma Clearance is highly dependent on hepatic blood flow (flow-limited) Clearance approaches zero because so little drug escapes the liver

Correct Answer:

Clearance is highly dependent on hepatic blood flow (flow-limited)

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