Plovdiv Entrance Practice Test

In skeletal muscle histology, what is the correct order from the outermost to the innermost unit?

Epimysium, fascicles (perimysium), individual muscle fibres (endomysium), sarcolemma, myofibrils, sarcomeres Epimysium, endomysium, fascicles, sarcolemma, myofibrils, sarcomeres Perimysium, epimysium, endomysium, sarcolemma, myofibrils, sarcomeres Endomysium, perimysium, epimysium, sarcolemma, myofibrils, sarcomeres

Correct Answer:

Epimysium, fascicles (perimysium), individual muscle fibres (endomysium), sarcolemma, myofibrils, sarcomeres

Explanation:

The arrangement goes from the outer protective layers to the inner contractile machinery. The whole muscle is enclosed by the epimysium. Inside, it’s organized into bundles called fascicles, each wrapped by the perimysium. Within those fascicles lie individual muscle fibers, each surrounded by the endomysium. The muscle fiber itself has its own membrane, the sarcolemma, just inside the endomysium. Inside the fiber, the long cylindrical elements are myofibrils, which contain the repeating units called sarcomeres—the basic contractile blocks. So the order from outside to inside is epimysium, fascicles with perimysium, individual muscle fibers with endomysium, sarcolemma, myofibrils, and then sarcomeres.

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