OMSB Pharmacist Exam Practice Questions - OMSB Licensing Examination - Pharmacist (CBT Via Prometric) Exam

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A patient stabilised on warfarin is started on amiodarone for atrial fibrillation. What is the expected interaction and the appropriate management?

Amiodarone inhibits warfarin metabolism; empirically reduce the warfarin dose and monitor INR Amiodarone induces warfarin metabolism; increase the warfarin dose No clinically significant interaction occurs; continue the same dose Amiodarone displaces warfarin from albumin requiring an immediate dose increase

Correct Answer:

Amiodarone inhibits warfarin metabolism; empirically reduce the warfarin dose and monitor INR

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