OME Cardiac Modules Practice Test

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Phase 0 of the SA node action potential occurs due to entry of which ion?
Correct Answer:
Calcium enters
Explanation:
Phase 0 in the SA node is driven by calcium entry through L-type calcium channels. Pacemaker cells rely on Ca2+ for the rapid depolarization because they lack the fast Na+ current that drives phase 0 in ventricular tissue. The Ca2+ influx raises the membrane potential to initiate the upstroke. Sodium entering would mainly depolarize in non-pacemaker heart tissue, potassium leaving would hyperpolarize/repolarize, and chloride influx isn’t responsible for this rapid depolarization.

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