OME Cardiac Modules Practice Test

Necrotic lipid core of a plaque contains which components?

HDL and phospholipids LDL, cholesterol, dead foam cells, oxidized LDL Smooth muscle cells and collagen Calcium deposits

Correct Answer:

LDL, cholesterol, dead foam cells, oxidized LDL

Explanation:

The necrotic lipid core in an atherosclerotic plaque is made up of cholesterol-rich debris derived from modified LDL taken up by macrophages, which become foam cells. When these foam cells die, they release cholesterol, cholesterol esters, and other lipid-rich material into the plaque center. Oxidized LDL is a key player, promoting more uptake by macrophages and sustaining inflammation that enlarges the core. HDL, smooth muscle cells with collagen, and calcium deposits play other roles in the plaque structure or its stability, but they are not the defining contents of the necrotic lipid core.

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