ObGyn Board Practice Questions - Saudi Board Obstetrics And Gynecology Final Written Exam

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A 32-year-old G1P0 at 11 weeks of gestation presents to the clinic to discuss prenatal screening for fetal aneuploidies. She has no significant medical history. Which of the following screening tests offers the highest sensitivity and specificity for Down syndrome (trisomy 21)?

First-trimester combined screening (PAPP-A, beta-hCG, and nuchal translucency) Second-trimester quadruple screening (MSAFP, hCG, estriol, and inhibin A) Cell-free DNA (cfDNA) screening Integrated screening (first- and second-trimester markers combined)

Correct Answer:

Cell-free DNA (cfDNA) screening

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