NPLEX II Minor Surgery Practice Test

Isotretinoin is known to carry which major safety risk that requires monitoring?

It is a desired effect It is a potential adverse effect requiring monitoring It occurs only with topical isotretinoin It has no safety concerns

Correct Answer:

It is a potential adverse effect requiring monitoring

Explanation:

Main concept: Isotretinoin has major safety risks that require ongoing monitoring. This drug is highly teratogenic, so pregnancy must be prevented and frequent pregnancy testing and contraception are required during treatment. In addition, it can cause hepatotoxicity and lipid abnormalities, so liver function tests and lipid panels are monitored regularly. Because of these significant safety concerns, the idea that it’s just a desired effect or that it has no safety concerns is incorrect, and safety issues are present with systemic use (not just topical). The option describing it as a potential adverse effect requiring monitoring best captures why monitoring is essential.

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