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NCC Board Certification As A Neonatal Nurse Practitioner (NNP-BC) Practice Test

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Beckwith-Wiedemann syndrome neonates have a high risk for which anomaly?
Correct Answer:
Omphalocele
Explanation:
Beckwith-Wiedemann syndrome is an overgrowth disorder due to dysregulation of imprinted genes on chromosome 11p15.5, and a hallmark finding is an omphalocele, where abdominal contents herniate through the umbilicus due to incomplete abdominal wall closure. This association makes omphalocele the most characteristic anomaly in affected neonates. Other options like hydrocephalus, anencephaly, or cleft lip are not typical features of Beckwith-Wiedemann syndrome, so omphalocele best fits the classic pattern of findings seen with this condition.

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