NBME Microbiology Practice Test

Clonorchis sinensis infection is most commonly acquired through which route?

Undercooked fish Undercooked pork Contaminated water Inhalation of eggs

Correct Answer:

Undercooked fish

Explanation:

Clonorchis sinensis infection is acquired by eating raw or undercooked freshwater fish containing metacercariae. Once swallowed, these larvae excyst in the intestine and migrate to the biliary ducts, where they mature and lay eggs that exit in the stool. The life cycle requires the fish as the second intermediate host, which is why undercooked fish is the route of infection. Pork would transmit different parasites, contaminated water is not how this fluke typically enters the body, and inhaling eggs isn’t a transmission route for clonorchiasis.

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