NBME CBSSA Practice Questions - NBME Comprehensive Basic Science Self-Assessment Exam

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A 49-year-old woman has episodic burning pain in her hands and feet with redness. Laboratory studies show platelets of 950,000/mm3 and a JAK2 mutation. Which mechanism best explains her painful episodes?

Immune complex deposition in small vessels Platelet-mediated microvascular occlusion Defective collagen cross-linking in vessel walls Antibody-mediated destruction of peripheral nerves

Correct Answer:

Platelet-mediated microvascular occlusion

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