NBME CBSSA Practice Questions - NBME Comprehensive Basic Science Self-Assessment Exam

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A 23-year-old man develops dark urine and back pain 2 days after taking primaquine for malaria prophylaxis. Peripheral smear shows bite cells and Heinz bodies. Which biochemical abnormality most directly explains this reaction?

Impaired generation of NADPH in the pentose phosphate pathway Defective conversion of pyruvate to acetyl-CoA Decreased synthesis of heme from glycine and succinyl-CoA Impaired reduction of methemoglobin by cytochrome b5 reductase

Correct Answer:

Impaired generation of NADPH in the pentose phosphate pathway

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