Natera Panorama Practice Exam

Which chromosomal conditions are included in the standard Panorama report (excluding microdeletions)?

Only sex chromosome aneuploidies Trisomies 21, 18, and 13, plus common sex chromosome aneuploidies Neural tube defects All trisomies including 16 and 22

Correct Answer:

Trisomies 21, 18, and 13, plus common sex chromosome aneuploidies

Explanation:

Panorama’s standard report focuses on the chromosomal changes that cfDNA testing detects most reliably: trisomies 21, 18, and 13, together with the most common sex chromosome aneuploidies. This scope reflects what the test can consistently identify in maternal blood for a typical pregnancy. Microdeletions are not part of the standard report (they’re offered as a separate panel). Neural tube defects aren’t included because this cfDNA test isn’t designed to detect them. Also, not all trisomies are reported in the standard panel—trisomies such as 16 and 22 aren’t part of it due to limited clinical utility and interpretive challenges. Therefore, the standard Panorama report includes trisomies 21, 18, and 13 plus common sex chromosome aneuploidies.

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