NAPLEX Contraception And Infertility Practice Test

Compared with combined oral contraceptives, estrogen exposure from vaginal rings is typically:

Lower Higher About the same Not applicable

Correct Answer:

Lower

Explanation:

Estrogen exposure depends on how much estrogen reaches the circulation and how it’s delivered. The vaginal ring releases estrogen steadily at a lower daily amount directly into the bloodstream (about 15 micrograms of ethinyl estradiol per day) and bypasses the liver on first absorption. In contrast, most combined oral contraceptives provide a higher daily dose of estrogen (commonly 20–35 micrograms per tablet) taken every day, which leads to greater overall estrogen exposure over the cycle. The ring’s lower daily dose and delivery route mean less estrogen circulating systemically compared with typical oral contraceptives, so estrogen exposure is typically lower.

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