NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

What is the main action of PAMORAS on opioid-induced constipation?

Increase bulk formation Stimulate peristalsis Block opioid receptors in the gut Reduce intestinal fluid absorption

Correct Answer:

Block opioid receptors in the gut

Explanation:

PAMORAS is a medication used to treat opioid-induced constipation. This means that the main action of PAMORAS is to address constipation caused by the use of opioids. Option A and B are incorrect because they both refer to actions that aim to alleviate constipation in general rather than specifically addressing opioid-induced constipation. Option D is incorrect because it suggests reducing intestinal fluid absorption would address opioid-induced constipation, which is not the case. The correct answer, Option C, refers to blocking opioid receptors in the gut, which is the main mechanism of action of PAMORAS in addressing constipation caused by opioids. By doing so, PAMORAS can help alleviate constipation and improve bowel movements for individuals who use opioids.

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