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MT AAB Immunohematology Practice Test

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As part of daily quality control, anti-B is tested against B cells. This procedure ensures what property of the antibody?
Correct Answer:
Antibody specificity
Explanation:
Antibody specificity. By testing anti-B against cells that carry the B antigen, you confirm that the reagent binds specifically to the B determinant and not to other cellular components. This ensures the antibody will react only with B antigen-bearing cells in routine testing, providing reliable, selective identification of the B antigen. This single QC step doesn’t measure how much antibody is present (titer), the antibody’s class (isotype), or the overall binding strength in multiple interactions (avidity); those require different tests or approaches.

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