MRCPCH AKP Practice Questions - MRCPCH Applied Knowledge In Practice (AKP) Exam

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A 4-year-old boy has recurrent severe bacterial infections including two episodes of pneumococcal pneumonia and one of meningococcal sepsis, plus a Neisseria infection. Complement studies show a markedly reduced CH50 with normal C3 and C4. Which immunological abnormality best explains this pattern?

X-linked agammaglobulinaemia Chronic granulomatous disease Selective IgA deficiency Terminal complement pathway (C5-C9) deficiency

Correct Answer:

Terminal complement pathway (C5-C9) deficiency

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