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Microbial Growth Phases, Oxygen Needs, And Immunity Types Practice Test

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Which large, mononuclear phagocytic cell differentiates into macrophages after migrating into tissues?
Correct Answer:
Monocytes
Explanation:
Monocytes are produced in the bone marrow and circulate in the blood. When they migrate into tissues during infection or inflammation, they differentiate into macrophages, becoming large phagocytic cells that engulf microbes and debris and present antigens to T cells. This transformation is the defining step that links circulating monocytes to tissue macrophages. Lymphocytes are primarily involved in adaptive immunity, neutrophils are rapid first responders that phagocytose but do not differentiate into macrophages, and eosinophils deal with parasites and allergic responses rather than becoming macrophages.

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