Mehlman High Yield Risk Factors Practice Test

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An 8-year-old with a long history of recurrent pulmonary infections and progressive peripheral neuropathy is most consistent with which diagnosis, given fat-soluble vitamin deficiencies?
Correct Answer:
Cystic fibrosis
Explanation:
Fat-soluble vitamins (A, D, E, and K) depend on proper fat digestion and pancreatic enzymes to be absorbed. When fat absorption is impaired, as in fat-malabsorption syndromes, you see deficiencies of these vitamins. In a child with long-standing recurrent pulmonary infections, think of a condition that causes both chronic lung disease and exocrine pancreatic insufficiency. Cystic fibrosis fits perfectly: thick mucus blocks the airways leading to infections, and the pancreatic ducts become obstructed, reducing enzyme delivery to the gut and causing fat malabsorption. That malabsorption explains the fat-soluble vitamin deficiencies, and the neuropathy can be a manifestation of vitamin E deficiency. The other options don’t link chronic lung infections with fat-malabsorption–related vitamin deficiencies in a way that matches this presentation.

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