Kroger Pharmacy Technician Practice Test

Hydrochlorothiazide is classified as which type of diuretic?

Loop diuretic Thiazide diuretic Osmotic diuretic Potassium-sparing diuretic

Correct Answer:

Thiazide diuretic

Explanation:

Hydrochlorothiazide is a thiazide diuretic because it specifically inhibits the Na+-Cl− cotransporter in the distal convoluted tubule, reducing sodium and water reabsorption there and producing a mild to moderate diuresis. This mechanism distinguishes it from loop diuretics, which act in the loop of Henle, and from osmotic diuretics, which create an osmotic gradient, or from potassium-sparing diuretics, which affect aldosterone receptors or epithelial sodium channels to conserve potassium. Thiazides like hydrochlorothiazide also tend to increase calcium reabsorption, a helpful note in clinical contexts such as kidney stone prevention. In short, its site of action and mechanism align with the thiazide class.

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