Japan Pharmacist Exam Practice Questions - Japan National Pharmacist Examination (Yakuzaishi Kokka Shiken) Exam

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A weakly acidic drug is retained too strongly on a reversed-phase HPLC column. Which adjustment is most likely to shorten its retention time by increasing ionization?

Lower the mobile-phase pH far below the drug pKa Raise the mobile-phase pH above the drug pKa Decrease the organic solvent fraction Use a longer C18 column with the same mobile phase

Correct Answer:

Raise the mobile-phase pH above the drug pKa

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