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INBDE Pharmacology Practice Test

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Which drug is a short-acting local anesthetic?
Correct Answer:
Procaine
Explanation:
Local anesthetics differ in how long they last based on their chemical structure. Esters are typically hydrolyzed quickly in the blood by plasma cholinesterases, which shortens their duration. Procaine is an ester-type local anesthetic, so it is broken down rapidly and provides only a brief duration of anesthesia. In contrast, lidocaine and prilocaine are amides with longer duration, and bupivacaine is long-acting. Therefore, procaine best matches a short-acting local anesthetic.

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