General Surgery Board Practice Questions - Saudi Board General Surgery Final Written Exam

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A 55-year-old postoperative patient who has been receiving prophylactic unfractionated heparin develops a sudden drop in platelet count from 250,000 to 90,000/microL on postoperative day 7, accompanied by a new cold, painful left leg. What is the most appropriate next step in management?
Correct Answer:
Discontinue heparin and initiate a direct thrombin inhibitor (e.g., argatroban)

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