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Facharzt FMH Pneumologie Practice Questions - Facharzt FMH Für Pneumologie Spécialiste FMH En Pneumologie Exam

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A 48-year-old non-smoker with severe refractory asthma has experienced three oral corticosteroid-treated exacerbations in the past 12 months despite adherence to high-dose fluticasone-salmeterol plus tiotropium. Peripheral blood testing reveals an absolute eosinophil count of 480 cells/µL (0.48 × 10⁹/L), total serum IgE of 42 IU/mL, and fractional exhaled nitric oxide (FeNO) of 38 ppb. Skin prick testing for common aeroallergens is negative. Which biologic therapy is most specifically indicated for this patient's phenotype?
Correct Answer:
Mepolizumab or Benralizumab (targeting the IL-5 pathway)

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