Facharzt FMH Pathologie Practice Questions - Facharzt FMH Für Pathologie Spécialiste FMH En Pathologie Exam

Access More Questions

An endoscopic mucosal resection (EMR) specimen from the distal esophagus reveals a 1.2 cm ulcerated lesion. Histology demonstrates sheets of malignant polygonal cells with abundant dense eosinophilic cytoplasm, prominent intercellular bridges, and focal keratin pearl formation infiltrating the lamina propria. Immunohistochemistry confirms diffuse strong positivity for p40 and cytokeratin 5/6, while CK7 and CDX2 are completely negative. How should this entity be diagnosed and distinguished from conventional distal esophageal adenocarcinoma?

Adenocarcinoma with squamous metaplasia; staged as pT1b. Esophageal squamous cell carcinoma (SCC); distinguished by p40/CK5/6 positivity and keratinization. Adenosquamous carcinoma of the gastroesophageal junction; driven by HER2 gene amplification. Poorly differentiated neuroendocrine carcinoma (small cell type); confirmed by p40 expression.

Correct Answer:

Esophageal squamous cell carcinoma (SCC); distinguished by p40/CK5/6 positivity and keratinization.

Access more questions from this quiz

Continue to Facharzt FMH Pathologie Practice Questions - Facharzt FMH für Pathologie Spécialiste FMH en pathologie Exam for more practice questions and the full quiz experience.

Access More Questions