Facharzt FMH Pathologie Practice Questions - Facharzt FMH Für Pathologie Spécialiste FMH En Pathologie Exam

Access More Questions

A 58-year-old man with a 15-year history of gastroesophageal reflux disease undergoes surveillance endoscopy for Barrett esophagus. Biopsies of salmon-colored columnar-lined mucosa show crowded glandular architecture, loss of nuclear polarity, marked nuclear pleomorphism with hyperchromasia extending to the mucosal surface, atypical mitotic figures near the luminal surface, and complete absence of surface maturation. Immunohistochemistry for p53 demonstrates strong, diffuse, unequivocal nuclear overexpression in 100% of the atypical epithelial cells. What is the most accurate pathological diagnosis according to current WHO classification criteria?

Barrett esophagus with high-grade dysplasia (HGD). Barrett esophagus with low-grade dysplasia (LGD). Barrett esophagus negative for dysplasia with florid reactive/regenerative atypia. Intramucosal esophageal adenocarcinoma with submucosal invasion.

Correct Answer:

Barrett esophagus with high-grade dysplasia (HGD).

Access more questions from this quiz

Continue to Facharzt FMH Pathologie Practice Questions - Facharzt FMH für Pathologie Spécialiste FMH en pathologie Exam for more practice questions and the full quiz experience.

Access More Questions