Fachapotheker In FPH Spital Practice Questions - Fachapotheker In FPH In Spitalpharmazie Pharmacien Ne Spécialiste FPH En Pharmacie Hospitalière Exam

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A 62-year-old male ICU patient (weight 75 kg, serum creatinine 110 µmol/L) with severe MRSA hospital-acquired pneumonia is receiving IV vancomycin. According to current consensus guidelines on therapeutic drug monitoring (TDM) of vancomycin, what is the primary pharmacokinetic/pharmacodynamic (PK/PD) target index for clinical efficacy and nephrotoxicity minimization in serious MRSA infections?

Target area under the 24-hour concentration-time curve to minimum inhibitory concentration ratio (AUC24/MIC) of 400 to 600 mg·h/L (assuming MIC by broth microdilution = 1 mg/L) Target steady-state peak serum concentration (Cpeak) of 60 to 80 mg/L measured 1 hour after completing a 60-minute infusion Target isolated trough serum concentration (Ctrough) of 25 to 30 mg/L measured immediately prior to the fourth dose Target time above the minimum inhibitory concentration (fT>MIC) of 100% of the dosing interval with trough levels maintained below 5 mg/L

Correct Answer:

Target area under the 24-hour concentration-time curve to minimum inhibitory concentration ratio (AUC24/MIC) of 400 to 600 mg·h/L (assuming MIC by broth microdilution = 1 mg/L)

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