Examen Integrado Farmacia Hospitalaria Practice Questions - Examen Integrado De Residencias De La Salud - Farmacia Hospitalaria (Argentina) Exam

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Under hospital Antimicrobial Stewardship Programs (PROA - Programas de Optimización de Antimicrobianos), which pharmacokinetic/pharmacodynamic (PK/PD) index best predicts the clinical and bacteriological efficacy of beta-lactam antibiotics such as piperacillin/tazobactam and meropenem in critically ill patients?

The ratio of maximum peak serum concentration to minimum inhibitory concentration (Cmax/MIC) The percentage of the dosing interval during which the free (unbound) drug concentration exceeds the MIC (%fT > MIC) The ratio of the 24-hour area under the concentration-time curve to the MIC (AUC24/MIC) The post-antibiotic effect (PAE) duration exceeding the dosing interval

Correct Answer:

The percentage of the dosing interval during which the free (unbound) drug concentration exceeds the MIC (%fT > MIC)

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