EDAPT Intracranial Regulation Practice Test

Which assessment finding with tolcapone is most concerning?

Nausea Dizziness Yellowing of eyes and skin Headache

Correct Answer:

Yellowing of eyes and skin

Explanation:

Tolcapone carries a risk of liver toxicity, so signs of liver injury are the most concerning. Yellowing of the eyes and skin indicates jaundice, a telltale sign that bilirubin is building up because the liver isn’t processing it properly. This can progress to serious liver dysfunction, so it signals the need to stop tolcapone and promptly check liver function tests and bilirubin levels, then notify the clinician. Other listed side effects like nausea, dizziness, or headache can occur with many drugs and are typically less alarming, not signaling imminent severe harm the way jaundice does.

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