Drug Action 2 Exam 2 Practice

What are the products of acetylcholine hydrolysis by acetylcholinesterase?

Acetic acid and choline Acetate and choline Acetic anhydride and choline Water and choline

Correct Answer:

Acetic acid and choline

Explanation:

Hydrolysis of acetylcholine by acetylcholinesterase breaks the ester bond between the acetyl group and the choline moiety, yielding choline and the acetyl group. In water, that acetyl group appears as acetic acid; in physiological conditions (around neutral pH) it exists mainly as acetate. So the immediate hydrolysis products are choline and acetic acid, with acetate being the predominant form in body fluids. That's why acetic acid and choline is the best answer here: it reflects the actual hydrolysis products, while recognizing that the form present in the body is usually acetate.

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