CMSA Diploma In Anaesthesia DA(SA) Practice Questions - Diploma In Anaesthesia Of The College Of Anaesthetists Of South Africa Exam

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A 35-year-old patient receives propofol for induction of anaesthesia. What primary mechanism accounts for the rapid termination of its central hypnotic effect following a single bolus dose?

Extensive hepatic metabolism by cytochrome P450 enzymes Rapid redistribution from brain tissue to less vascular muscle and fat tissues Renal excretion of unchanged active propofol drug molecules Extrahepatic pulmonary breakdown by plasma esterases

Correct Answer:

Rapid redistribution from brain tissue to less vascular muscle and fat tissues

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