CMSA Cert Allergology(SA) Phys Practice Questions - CMSA Sub-specialty Certificate In Allergology Cert Allerg(SA) Phys - South Africa Exam

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According to the revised Gell and Coombs classification of hypersensitivity reactions, which mechanism correctly pairs a severe adverse drug reaction with its underlying immunological subtype?

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) — Type IVb hypersensitivity mediated by Th2 cells, IL-4, IL-5, and eosinophils Serum Sickness — Type IVc hypersensitivity mediated by cytotoxic CD8+ T cells releasing perforin and granzyme B Acute Generalized Exanthematous Pustulosis (AGEP) — Type I IgE-mediated anaphylactic degranulation of basophils Stevens-Johnson Syndrome (SJS) — Type II antibody-dependent cell-mediated cytotoxicity mediated by NK cells and IgG antibodies

Correct Answer:

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) — Type IVb hypersensitivity mediated by Th2 cells, IL-4, IL-5, and eosinophils

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