CMSA Cert Allergology(SA) Phys Practice Questions - CMSA Sub-specialty Certificate In Allergology Cert Allerg(SA) Phys - South Africa Exam

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A 28-year-old female presents with severe seasonal allergic rhinitis. Immunological evaluation reveals naive CD4+ T cell differentiation biased toward the Th2 lineage. Which cytokine and transcription factor combination is uniquely responsible for driving Th2 cell commitment?

IL-4 signaling through STAT6 to induce GATA-3 transcription factor expression IL-12 signaling through STAT4 to induce T-bet transcription factor expression IL-27 signaling through STAT1 to induce Eomesodermin expression IL-6 and TGF-β signaling through STAT3 to induce RORγt expression

Correct Answer:

IL-4 signaling through STAT6 to induce GATA-3 transcription factor expression

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