CMSA Cert Allergology(SA) Phys Practice Questions - CMSA Sub-specialty Certificate In Allergology Cert Allerg(SA) Phys - South Africa Exam

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Following allergen-mediated cross-linking of membrane-bound IgE on mast cells, which immediate intracellular signaling event initiates the phosphorylation cascade of the high-affinity IgE receptor (FcεRI)?

Direct binding of Janus kinase 2 (JAK2) to the unphosphorylated α subunit cytoplasmic tail Cleavage of membrane phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C gamma 1 (PLCγ1) without upstream kinase activity Activation of the receptor-associated Src-family tyrosine kinase Lyn, which phosphorylates ITAM motifs on β and γ subunits Dephosphorylation of the γ subunit by SHP-1 protein tyrosine phosphatase

Correct Answer:

Activation of the receptor-associated Src-family tyrosine kinase Lyn, which phosphorylates ITAM motifs on β and γ subunits

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