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CMID Practice Test
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Which of the following is NOT included in the IHC panel for primary ovarian carcinoma?
BRCA1
WT1
CA-125
HER2
Reveal Answer
Correct Answer:
BRCA1
Explanation:
In immunohistochemistry, the goal is to detect specific proteins in tissue to help classify the tumor and its origin. WT1 is a classic marker that supports serous ovarian carcinoma, and HER2 can be evaluated in some ovarian cancers for targeted therapy considerations. CA-125 is tied to ovarian cancer as a serum marker and can be detected in tissue in some settings, though its primary role is not as an IHC workhorse. BRCA1, by contrast, is a gene whose status is determined by genetic/molecular testing (sequencing, deletion/duplication analysis) rather than an immunohistochemical stain. It informs hereditary risk and PARP-inhibitor therapy, not the routine histologic panel used to identify ovarian carcinoma. So BRCA1 is not included in the IHC panel.
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