Cert Endocrinology(SA) Phys Practice Questions - CMSA Sub-specialty Certificate In Endocrinology And Metabolism Exam

What is the primary physiological mechanism by which SGLT2 inhibitors lower blood glucose levels?

Inhibition of sodium-glucose cotransporter 2 in the renal proximal convoluted tubule, inducing glucosuria Enhancement of peripheral insulin sensitivity in skeletal muscle via PPAR-gamma activation Inhibition of hepatic gluconeogenesis via AMP-activated protein kinase activation Stimulation of insulin secretion from pancreatic beta cells in a glucose-dependent manner

Correct Answer:

Inhibition of sodium-glucose cotransporter 2 in the renal proximal convoluted tubule, inducing glucosuria

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