BCGP Practice Questions - Board Certified Geriatric Pharmacist Exam

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A 90-year-old male with a creatinine clearance of 25 mL/min is prescribed digoxin for heart failure. How would you expect the volume of distribution (Vd) of digoxin to be affected in this patient?

Increased due to increased body fat Decreased due to reduced lean body mass and total body water Unchanged, as digoxin is not affected by age Increased due to decreased plasma protein binding

Correct Answer:

Decreased due to reduced lean body mass and total body water

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