ASCP International (ASCPi) Practice Exam

In terms of LAP score, which statement is true for CML?

LAP score is typically increased LAP score is typically decreased LAP score is variable and unpredictable LAP score is irrelevant

Correct Answer:

LAP score is typically decreased

Explanation:

LAP score measures alkaline phosphatase activity in neutrophils. In chronic myeloid leukemia, neutrophils arise from a malignant clone with impaired maturation and reduced enzyme activity, so the LAP score is typically decreased. This helps distinguish CML from a leukemoid reaction, where neutrophils are highly activated and the LAP score is elevated. Hence the statement that LAP score is typically decreased is true.

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