Veterinary Technician National Examination (VTNE)

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A veterinarian is planning to use gabapentin as part of a multi-modal analgesic plan for a dog with chronic neuropathic pain. What is the primary mechanism of action for gabapentin's analgesic effect?

It acts as a direct agonist at GABA receptors, increasing inhibitory neurotransmission. It is a potent mu-opioid receptor agonist, similar to morphine. It binds to a subunit of voltage-gated calcium channels, reducing the release of excitatory neurotransmitters. It non-selectively inhibits both COX-1 and COX-2 enzymes, reducing prostaglandin synthesis.

Correct Answer:

It binds to a subunit of voltage-gated calcium channels, reducing the release of excitatory neurotransmitters.

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