Schleswig-Holstein Abitur Biology Practice Questions - Schleswig-Holstein Zentralabitur Biology (Biologie) Exam

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Why does pepsin, a stomach enzyme, work best at a strongly acidic pH of around 2, while most human enzymes prefer near-neutral pH?

Each enzyme has evolved an optimal pH matching the ionic environment it normally functions in, since pH affects the charge of amino acid side chains that shape the active site Pepsin is not actually a protein and is therefore unaffected by pH All enzymes function identically regardless of surrounding pH Acidic pH always destroys enzyme activity completely

Correct Answer:

Each enzyme has evolved an optimal pH matching the ionic environment it normally functions in, since pH affects the charge of amino acid side chains that shape the active site

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