ELSO Adult ECMO Certification Exam

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Unfractionated heparin achieves its anticoagulant effect in the ECMO circuit primarily through which mechanism of action?

Directly binding to and inhibiting thrombin (Factor IIa). Chelating calcium ions, which are essential for the coagulation cascade. Preventing the aggregation of platelets on the circuit surface. Binding to antithrombin, greatly accelerating its inactivation of thrombin and Factor Xa.

Correct Answer:

Binding to antithrombin, greatly accelerating its inactivation of thrombin and Factor Xa.

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